Na/K-ATPase ligands, ouabain antagonists, assays and uses thereof

Summary
Full Description

The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative.

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Abstract/Description:	The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative.
Date Issued:	2015-08-25

Abstract/Description:

The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative.

Date Issued:

2015-08-25

Title:	Na/K-ATPase ligands, ouabain antagonists, assays and uses thereof.
Name(s):	The University of Toledo, assignee Xie, Zi-jian, inventor Shapiro, Joseph I., inventor Si, Shuyi, inventor Zhang, Zhongbing, inventor
Type of Resource:	text
Genre:	patent
Publisher:	United States Patent and Trademark Office
Other Date:	Date Filed: 2013-10-03
Date Issued:	2015-08-25
Physical Form:	application/pdf
Extent:	23 p.
Abstract/Description:	The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative.
Identifier(s):	utpatents-US9114126 (IID) Patent No.: US9114126 (patno) Appl. No.: 14/045269 (appno)
Held by:	United States Patent and Trademark Office (USPTO) Public Search Facility
Location:	University of Toledo Digital Repository
Rights Statement:	No Copyright - United States
In Collections:	University of Toledo U.S. Patents