Na/K-ATPase ligands, ouabain antagonists, assays and uses thereof
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Abstract/Description: | The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. |
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Date Issued: | 2015-08-25 |
Title: | Na/K-ATPase ligands, ouabain antagonists, assays and uses thereof. |
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Name(s): |
The University of Toledo, assignee Xie, Zi-jian, inventor Shapiro, Joseph I., inventor Si, Shuyi, inventor Zhang, Zhongbing, inventor |
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Type of Resource: | text | |
Genre: | patent | |
Publisher: | United States Patent and Trademark Office | |
Other Date: | Date Filed: 2013-10-03 | |
Date Issued: | 2015-08-25 | |
Physical Form: | application/pdf | |
Extent: | 23 p. | |
Abstract/Description: | The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. | |
Identifier(s): |
utpatents-US9114126 (IID) Patent No.: US9114126 (patno) Appl. No.: 14/045269 (appno) |
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Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | No Copyright - United States | |
In Collections: |