Improving efficacy of cancer therapy
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Abstract/Description: | Embodiments of the invention provide a method of improving the efficacy of an anti-cancer therapy and a method of treatment of cancer by normalizing angiogenesis in cancer. By enhancing the cell signaling pathway via a TRPV4 receptor in tumor endothelial cells, either by a TRPV4 agonist or by increasing the expression of TRPV4 in the tumor endothelial cells, the tumor endothelial cells behave normally and form normal angiogenic network for better anti-cancer therapy to the tumors. |
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Date Issued: | 2015-07-14 |
Title: | Improving efficacy of cancer therapy. |
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Name(s): |
Children's Medical Center Corporation, assignee Thodeti, Charles K., inventor Ingber, Donald E., inventor |
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Type of Resource: | text | |
Genre: | patent | |
Publisher: | United States Patent and Trademark Office | |
Other Date: | Date Filed: 2011-06-22 | |
Date Issued: | 2015-07-14 | |
Physical Form: | application/pdf | |
Extent: | 53 p. | |
Abstract/Description: | Embodiments of the invention provide a method of improving the efficacy of an anti-cancer therapy and a method of treatment of cancer by normalizing angiogenesis in cancer. By enhancing the cell signaling pathway via a TRPV4 receptor in tumor endothelial cells, either by a TRPV4 agonist or by increasing the expression of TRPV4 in the tumor endothelial cells, the tumor endothelial cells behave normally and form normal angiogenic network for better anti-cancer therapy to the tumors. | |
Identifier(s): |
utpatents-US9078856 (IID) Patent No.: US9078856 (patno) Appl. No.: 13/703765 (appno) |
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Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
Location: | University of Toledo Digital Repository | |
Rights Statement: | No Copyright - United States | |
In Collections: |