Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof

The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
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Abstract/Description: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
Subject(s): 514/339
435/366
435/375
514/419
546/277.4
546/278.1
548/493
Date Issued: 2015-05-05
Title: Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof.
Name(s): The University of Toledo, assignee
Maltese, William A., inventor
Erhardt, Paul W., inventor
Trabbic, Christopher, inventor
Overmeyer, Jean H., inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 2014-04-07
Date Issued: 2015-05-05
Physical Form: application/pdf
Extent: 86 p.
Abstract/Description: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
Identifier(s): utpatents-US9023871 (IID)
Patent No.: US9023871 (patno)
Appl. No.: 14/246558 (appno)
Subject(s): 514/339
435/366
435/375
514/419
546/277.4
546/278.1
548/493
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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