Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases

A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
Download pdf
Abstract/Description: A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
Subject(s): 530/326
530/300
530/324
Date Issued: 2012-10-09
Title: Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases.
Name(s): The University of Toledo, assignee
Xie, Zi-jian, inventor
Shapiro, Joseph I., inventor
Tian, Jiang, inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 2007-10-31
Date Issued: 2012-10-09
Physical Form: application/pdf
Extent: 70 p.
Abstract/Description: A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
Identifier(s): utpatents-US8283441 (IID)
Patent No.: US8283441 (patno)
Appl. No.: 12/446856 (appno)
Subject(s): 530/326
530/300
530/324
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
In Collections: