utpatents-US6630326
| Title: | Cancer diagnosis and therapy based on mutations in TGF-beta receptors. |
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|---|---|---|
| Name(s): |
Case Western Reserve University; Medical College of Ohio, assignee Markowitz, Sanford D., inventor Brattain, Michael G., inventor Willson V, James K., inventor |
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| Type of Resource: | text | |
| Genre: | patent | |
| Publisher: | United States Patent and Trademark Office | |
| Other Date: | Date Filed: 2001-06-13 | |
| Date Issued: | 2003-10-07 | |
| Physical Form: | application/pdf | |
| Extent: | 29 p. | |
| Abstract/Description: | This invention is based on the discovery that the type II TGF-beta receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis. | |
| Identifier(s): |
utpatents-US6630326 (IID) Patent No.: US6630326 (patno) Appl. No.: 09/878905 (appno) |
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| Subject(s): |
435/69.1 435/325 530/350 |
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| Held by: | United States Patent and Trademark Office (USPTO) Public Search Facility | |
| Location: | University of Toledo Digital Repository | |
| Rights Statement: | No Copyright - United States | |
| In Collections: |