Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging

A compound of formula (I): ##STR1## wherein, R1 is independently selected from methyl and ethyl and R2 is independently selected from hydrogen, alkyl, and substituted alkyl. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue. The present invention also relates to a method of administering the second sphere contrast agent.
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Abstract/Description: A compound of formula (I): ##STR1## wherein, R1 is independently selected from methyl and ethyl and R2 is independently selected from hydrogen, alkyl, and substituted alkyl. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue. The present invention also relates to a method of administering the second sphere contrast agent.
Subject(s): 424/9.361
Date Issued: 2001-09-25
Title: Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging.
Name(s): The University of Toledo; Schering Aktiengesellschaft, assignee
Davies, Julian A., inventor
Ebert, Wolfgang, inventor
Raduechel, Bernd, inventor
Schmitt-Willich, Heribert, inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 1999-01-11
Date Issued: 2001-09-25
Physical Form: application/pdf
Extent: 11 p.
Abstract/Description: A compound of formula (I): ##STR1## wherein, R1 is independently selected from methyl and ethyl and R2 is independently selected from hydrogen, alkyl, and substituted alkyl. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue. The present invention also relates to a method of administering the second sphere contrast agent.
Identifier(s): utpatents-US6294152 (IID)
Patent No.: US6294152 (patno)
Appl. No.: 09/227961 (appno)
Subject(s): 424/9.361
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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