Muscarinic receptor agonists

A compound of Formula (I): ##STR1## wherein R is independently selected from (CH2)9-12, (CH2 CH2)2 O, (CH2 CH2)3 O2, (CH2 CH2)4 O3, (CH2 CH2)5 O4, (CH2 CH2)6 O5 or (CH2 CH2 CH2)3 O2 ; or an acid addition salt or hydrate thereof. The compounds, with improved water solubility, have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
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Abstract/Description: A compound of Formula (I): ##STR1## wherein R is independently selected from (CH2)9-12, (CH2 CH2)2 O, (CH2 CH2)3 O2, (CH2 CH2)4 O3, (CH2 CH2)5 O4, (CH2 CH2)6 O5 or (CH2 CH2 CH2)3 O2 ; or an acid addition salt or hydrate thereof. The compounds, with improved water solubility, have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
Subject(s): 514/342
546/187
546/268.7
Date Issued: 2001-04-03
Title: Muscarinic receptor agonists.
Name(s): The University of Toledo, assignee
Messer, William S., inventor
Cao, Yang, inventor
Rajeswaran, Walajapet G., inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 2000-01-14
Date Issued: 2001-04-03
Physical Form: application/pdf
Extent: 9 p.
Abstract/Description: A compound of Formula (I): ##STR1## wherein R is independently selected from (CH2)9-12, (CH2 CH2)2 O, (CH2 CH2)3 O2, (CH2 CH2)4 O3, (CH2 CH2)5 O4, (CH2 CH2)6 O5 or (CH2 CH2 CH2)3 O2 ; or an acid addition salt or hydrate thereof. The compounds, with improved water solubility, have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
Identifier(s): utpatents-US6211204 (IID)
Patent No.: US6211204 (patno)
Appl. No.: 09/483334 (appno)
Subject(s): 514/342
546/187
546/268.7
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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