Method for modulating pigmentation by targeting BET bromodomain proteins

Methods, compositions, and kits useful for reducing pigmentation or treating hyperpigmentation disorders are disclosed. In accordance with the present disclosure, BET bromodomain protein inhibitors, such as JQ1, are used to reduce pigmentation, promote cell cycle arrest, inhibit the expression of TYR, TRP1, and DCT proteins, inhibit the expression of TYR mRNA, and suppress melanocyte proliferation.
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Abstract/Description: Methods, compositions, and kits useful for reducing pigmentation or treating hyperpigmentation disorders are disclosed. In accordance with the present disclosure, BET bromodomain protein inhibitors, such as JQ1, are used to reduce pigmentation, promote cell cycle arrest, inhibit the expression of TYR, TRP1, and DCT proteins, inhibit the expression of TYR mRNA, and suppress melanocyte proliferation.
Subject(s): A61K8/49
A61Q19/02
Date Issued: 2018-09-04
Title: Method for modulating pigmentation by targeting BET bromodomain proteins .
Name(s): The University of Toledo, assignee
De La Serna, Ivana, inventor
Trivedi, Archit, inventor
Type of Resource: text
Genre: patent
Publisher: United States Patent and Trademark Office
Other Date: Date Filed: 2014-12-11
Date Issued: 2018-09-04
Physical Form: application/pdf
Extent: 30 p.
Abstract/Description: Methods, compositions, and kits useful for reducing pigmentation or treating hyperpigmentation disorders are disclosed. In accordance with the present disclosure, BET bromodomain protein inhibitors, such as JQ1, are used to reduce pigmentation, promote cell cycle arrest, inhibit the expression of TYR, TRP1, and DCT proteins, inhibit the expression of TYR mRNA, and suppress melanocyte proliferation.
Identifier(s): utpatents-US10064798 (IID)
Patent No.: US10064798 (patno)
Appl. No.: 14/567033 (appno)
Subject(s): A61K8/49
A61Q19/02
Held by: United States Patent and Trademark Office (USPTO) Public Search Facility
Location: University of Toledo Digital Repository
Rights Statement: No Copyright - United States
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