Embodiments of the invention provide a method of improving the efficacy of an anti-cancer therapy and a method of treatment of cancer by normalizing angiogenesis in cancer. By enhancing the cell signaling pathway via a TRPV4 receptor in tumor endothelial cells, either by a TRPV4 agonist or by increasing the expression of TRPV4 in the tumor endothelial cells, the tumor endothelial cells behave normally and form normal angiogenic network for better anti-cancer therapy to the tumors.
Children's Medical Center Corporation
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The University of Toledo
University of Toledo Libraries
Thodeti, Charles K. and Ingber, Donald E., "Improving efficacy of cancer therapy" (2015). University of Toledo U.S. Patents. 5.