Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.
The United States of America, represented by the Secretary of Agriculture; Xavier University of Louisiana; The University of Toledo
These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.
The University of Toledo
University of Toledo Libraries
Erhardt, Paul W.; Khupse, Rahul S.; Sarver, Jefferey G.; Cleveland, Thomas E.; Boue, Stephen M.; Wiese, Thomas E.; Burow, Matthew E.; and Mclachlan, John A., "Methods for synthesizing glycinols, glyceollins I and II, compositions of selected intermediates, and therapeutic uses thereof" (2013). University of Toledo U.S. Patents. 38.