Abstract

Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.

Document Type

Patent

Primary Class

A61K33/24; A61K31/185; A61K31/255; A61K45/06; C07C309/47; C07C309/67; C07C309/73; C07C317/36; C07C323/66

Application Number

15/038585

Filing Date

11-25-2014

Patent Number

US9821008

Assignee(s)

The University of Toledo

Publication Date

11-21-2017

Patent Country

United States

Language

en_US

Institution

The University of Toledo

Repository

University of Toledo Digital Libraries

Digital Publisher

Digital Initiatives

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

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