Document Type

Patent

Abstract

A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. Also disclosed is use of said Src-modulating peptides for treatment of cancer.

Patent Country

United States

Patent Number

US9663561

Publication Date

5-30-2017

Assignee(s)

The University of Toledo

Application Number

14/607426

Filing Date

1-28-2015

Primary Class

A61K38/10; C07K14/47; A61K38/45; A61K38/46; C07K7/08; G01N33/573; A61K38/17

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

Institution

The University of Toledo

Repository

University of Toledo Digital Libraries

Digital Publisher

Digital Initiatives

Share

COinS