Abstract

The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.

Document Type

Patent

Primary Class

A61K38/04; A61K31/7048; A61K38/06; A61K38/07; A61K38/08; A61K38/10; C07K5/083; C07K5/103; C07K5/107; C07K5/11; C07K7/06; C07K7/08; C12N9/88

Secondary Class

A61K38/00

Application Number

14/069790

Filing Date

11-1-2013

Patent Number

US9301991

Assignee(s)

The University of Toledo

Publication Date

4-5-2016

Patent Country

United States

Language

en_US

Institution

The University of Toledo

Repository

University of Toledo Digital Libraries

Digital Publisher

Digital Initiatives

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

Share

COinS
 

Rights Statement

Rights Statement

No Copyright - United States. URI: http://rightsstatements.org/vocab/NoC-US/1.0/
The organization that has made the Item available believes that the Item is in the Public Domain under the laws of the United States, but a determination was not made as to its copyright status under the copyright laws of other countries. The Item may not be in the Public Domain under the laws of other countries. Please refer to the organization that has made the Item available for more information.