Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or Δ3 -Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin.
Medical College of Ohio; The Trustees of Columbia University
514/15.4; 514/21.1; 514/21.7; 514/807; 530/315; 930/21; 930/150; 930/260
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The University of Toledo
University of Toledo Libraries
Manning, Maurice and Sawyer, Wilbur H., "Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin" (1983). University of Toledo U.S. Patents. 230.