Document Type

Patent

Abstract

Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is methyl, ethyl, n-propyl, isopropyl or butyl; Tyr is D- or L-; W is Pro or Δ3 -Pro; and Z is L- or D- Arg. Related compounds in which X is H, methyl or ethyl; W is Pro and Val at the 4-position is replaced by Gln- have antivasopressor activity against arginine vasopressin. Compounds wherein D-Tyr is unetherified (X is H), W- is Pro and Z- is D- or L-Arg also act as antagonists of the antidiuretic activity of arginine vasopressin.

Patent Country

US

Patent Number

US4367225

Publication Date

1-4-1983

Assignee(s)

Medical College of Ohio; The Trustees of Columbia University

Application Number

06/247008

Filing Date

March 1981

Primary Class

514/10.9

Secondary Class

514/15.4; 514/21.1; 514/21.7; 514/807; 530/315; 930/21; 930/150; 930/260

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

Institution

The University of Toledo

Repository

University of Toledo Libraries

Digital Publisher

Digital Initiatives

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