Document Type

Patent

Abstract

Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula ##STR1## wherein n is 4 or 5; X is (D- or L-)Tyr(R), D-Phe, D-Val, D-Leu, D-lle, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn, D-Met or D-Gln; Y is Val, lle, Thr, Ala, Lys, Cha, Nva, Met, Nle, Orn, Ser, Asn, Gln, Phe, Tyr, Gly, Abu or Leu; Z is (D- or L-) Arg, Orn or Lys; Q is Arg(NH2), Ser(NH2), (D- or L-)Ala(NH2), Gly, OH or NH2 and R is methyl, ethyl, propyl or butyl; provided that, when Y is Gln or Val, R may also be H. Further compounds are those wherein Q is Orn(NH2), NHCH2 CH2 NH2, Val(NH2), Phe(NH2), lle(NH2), Thr(NH2), Pro(NH2) or Tyr(NH2).

Patent Country

US

Patent Number

US4649130

Publication Date

3-10-1987

Assignee(s)

Medical College of Ohio; The Trustees of Columbia University

Application Number

06/693870

Filing Date

January 1985

Primary Class

514/10.9

Secondary Class

514/15.4; 514/21.1; 514/807; 530/315; 930/20; 930/21; 930/150

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

Institution

The University of Toledo

Repository

University of Toledo Libraries

Digital Publisher

Digital Initiatives

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