Abstract

Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are degraded by the enzymes of the upper gastrointestinal tract or are transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine. In particular, the polymers contain divinylazobenzene compounds of the formulae ##STR1## wherein R1 and R2 are independently selected from the group consisting of H, (except that R1 and R2 are not both H), Cl, Br, I, NO2, NH2, RO, ArO, COOH or salts thereof, COOR, COOAr, CHO, COR, SO3 H or salts thereof, R or Ar and wherein R is alkyl of up to 18 carbon atoms and Ar is mono- or bicyclic aryl of up to 15 carbon atoms.

Document Type

Patent

Primary Class

514/10.9

Secondary Class

514/5.9; 514/10.3; 514/11.6; 514/54; 514/56; 514/150; 514/151; 514/568; 514/772; 514/778; 514/960; 514/961; 514/962; 514/963; 514/964; 534/573; 534/843; 534/DIG.3

Application Number

07/231491

Filing Date

August 1988

Patent Number

US5032572

Assignee(s)

Medical College of Ohio; Bowling Green State University

Publication Date

7-16-1991

Patent Country

US

Language

en_US

Institution

The University of Toledo

Repository

University of Toledo Libraries

Digital Publisher

Digital Initiatives

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

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Rights Statement

No Copyright - United States. URI: http://rightsstatements.org/vocab/NoC-US/1.0/
The organization that has made the Item available believes that the Item is in the Public Domain under the laws of the United States, but a determination was not made as to its copyright status under the copyright laws of other countries. The Item may not be in the Public Domain under the laws of other countries. Please refer to the organization that has made the Item available for more information.