Abstract

The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H3 -receptor antagonists. Such compounds have affinity for histamine H3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.

Document Type

Patent

Primary Class

514/319

Secondary Class

514/326; 514/397; 546/203; 546/210; 548/314.7

Application Number

08/145903

Filing Date

October 1993

Patent Number

US5486526

Assignee(s)

The University of Toledo; Gliatech, Inc.;

Publication Date

1-23-1996

Patent Country

US

Language

en_US

Institution

The University of Toledo

Repository

University of Toledo Libraries

Digital Publisher

Digital Initiatives

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

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Rights Statement

Rights Statement

No Copyright - United States. URI: http://rightsstatements.org/vocab/NoC-US/1.0/
The organization that has made the Item available believes that the Item is in the Public Domain under the laws of the United States, but a determination was not made as to its copyright status under the copyright laws of other countries. The Item may not be in the Public Domain under the laws of other countries. Please refer to the organization that has made the Item available for more information.