Document Type

Patent

Abstract

The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H3 -receptor antagonists. Such compounds have affinity for histamine H3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.

Patent Country

US

Patent Number

US5486526

Publication Date

1-23-1996

Assignee(s)

The University of Toledo; Gliatech, Inc.;

Application Number

08/145903

Filing Date

October 1993

Primary Class

514/319

Secondary Class

514/326; 514/397; 546/203; 546/210; 548/314.7

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

Institution

The University of Toledo

Repository

University of Toledo Libraries

Digital Publisher

Digital Initiatives

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