The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H3 -receptor antagonists. Such compounds have affinity for histamine H3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.
The University of Toledo; Gliatech, Inc.;
514/326; 514/397; 546/203; 546/210; 548/314.7
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The University of Toledo
University of Toledo Libraries
Durant, Graham J.; Khan, Amin M.; and Tedford, Clark E., "Histamine H3 -receptor antagonists and therapeutic uses thereof" (1996). University of Toledo U.S. Patents. 172.