A process for the preparation of a substituted guanidine by reacting a substituted cyanamide with ammonia or a substituted amine in the presence of a Lewis acid catalyst. Also disclosed is a process for the preparation of a tri-substituted guanidine by reacting a mono-substituted cyanamide with a di-substituted amine.
Cambridge Neuroscience, Inc.; The University of Toledo
546/134; 546/143; 546/306; 564/237; 564/239
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The University of Toledo
University of Toledo Libraries
Durant, Graham J. and Magar, Sharad S., "Preparation of substituted guanidines" (1996). University of Toledo U.S. Patents. 171.