Document Type

Patent

Abstract

This invention is based on the discovery that the type II TGF-β receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.

Patent Country

US

Patent Number

US5866323

Publication Date

2-2-1999

Assignee(s)

Case Western Reserve University; Medical College of Ohio

Application Number

08/445520

Filing Date

May 1995

Primary Class

435/6.11

Secondary Class

435/6.1; 435/7.1; 435/7.2; 435/7.21; 435/7.23; 436/503; 436/811

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

Institution

The University of Toledo

Repository

University of Toledo Libraries

Digital Publisher

Digital Initiatives

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