Abstract
The present invention relates to a method of inducing a Th1-like response against a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of overcoming suppression of interferon-γ (IFN-γ) expression in a neonatal host due to exposure of the neonatal host to a pathogen or an antigen, which comprises administering to the neonatal host an effective amount of IL-12 and the antigen. The present invention also relates to a method of enhancing the cytokine expression against or in response to a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen.
Document Type
Patent
Primary Class
424/85.2
Secondary Class
424/85.4; 424/184.1; 424/191.1; 424/204.1; 424/234.1; 424/264.1; 424/269.1; 530/350
Application Number
09/035593
Filing Date
March 1998
Patent Number
US5985264
Assignee(s)
Medical College of Ohio
Publication Date
11-16-1999
Patent Country
US
Language
en_US
Institution
The University of Toledo
Repository
University of Toledo Libraries
Digital Publisher
Digital Initiatives
Rights
These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.
Rights Statement
No Copyright - United States. URI: http://rightsstatements.org/vocab/NoC-US/1.0/
The organization that has made the Item available believes that the Item is in the Public Domain under the laws of the United States, but a determination was not made as to its copyright status under the copyright laws of other countries. The Item may not be in the Public Domain under the laws of other countries. Please refer to the organization that has made the Item available for more information.