Document Type

Patent

Abstract

The present invention relates to a method of inducing a Th1-like response against a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of overcoming suppression of interferon-γ (IFN-γ) expression in a neonatal host due to exposure of the neonatal host to a pathogen or an antigen, which comprises administering to the neonatal host an effective amount of IL-12 and the antigen. The present invention also relates to a method of enhancing the cytokine expression against or in response to a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen.

Patent Country

US

Patent Number

US5985264

Publication Date

11-16-1999

Assignee(s)

Medical College of Ohio

Application Number

09/035593

Filing Date

March 1998

Primary Class

424/85.2

Secondary Class

424/85.4; 424/184.1; 424/191.1; 424/204.1; 424/234.1; 424/264.1; 424/269.1; 530/350

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

Institution

The University of Toledo

Repository

University of Toledo Libraries

Digital Publisher

Digital Initiatives

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