The present invention relates to a method of inducing a Th1-like response against a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of overcoming suppression of interferon-γ (IFN-γ) expression in a neonatal host due to exposure of the neonatal host to a pathogen or an antigen, which comprises administering to the neonatal host an effective amount of IL-12 and the antigen. The present invention also relates to a method of enhancing the cytokine expression against or in response to a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL-12 and an antigen of the pathogen.
Medical College of Ohio
424/85.4; 424/184.1; 424/191.1; 424/204.1; 424/234.1; 424/264.1; 424/269.1; 530/350
These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.
The University of Toledo
University of Toledo Libraries
Metzger, Dennis W. and Arulanandam, Bernard P., "IL-12 Stimulation of Neonatal immunity" (1999). University of Toledo U.S. Patents. 134.