A compound of formula (I): ##STR1## wherein, R1, R2, R3 and R4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R1, R2 and R3, R4 are ring residues. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue, and a method of administering the second sphere contrast agent.
The University of Toledo; Schering Aktiengesellschaft
424/9.361; 514/182; 514/502; 514/836; 544/64; 544/78; 548/402; 548/523; 556/138; 556/139; 564/82
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The University of Toledo
University of Toledo Libraries
Davies, Julian A.; Ebert, Wolfgang; and Raduechel, Bernd, "Contrast agents for image enhancement in magnetic resonance imaging" (2000). University of Toledo U.S. Patents. 125.