Document Type

Patent

Abstract

This invention is based on the discovery that the type II TGFβ receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.

Patent Country

US

Patent Number

US6291237

Publication Date

9-18-2001

Assignee(s)

Case Western Reserve University; Medical College of Ohio

Application Number

09/239864

Filing Date

January 1999

Primary Class

435/325

Secondary Class

435/252.3; 435/254.11; 435/320.1; 435/419; 536/23.5; 536/24.31

Rights

These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.

Institution

The University of Toledo

Repository

University of Toledo Libraries

Digital Publisher

Digital Initiatives

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