Abstract
A method for removing acyl-groups appended by an ester linkage to the 2′-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions. 2′,7-bis-Monochloroacetylpaclitaxel analogs are converted to their corresponding 7-monochloroacetyl derivatives by treatment with alcohol under non-acidic conditions
Document Type
Patent
Primary Class
549/510
Secondary Class
549/511
Application Number
10/491576
Filing Date
September 2002
Patent Number
US6846937
Assignee(s)
The University of Toledo
Publication Date
1-25-2005
Patent Country
US
Language
en_US
Institution
The University of Toledo
Repository
University of Toledo Libraries
Digital Publisher
Digital Initiatives
Rights
These materials are free of copyright restrictions and are in the public domain within the United States only. The USPTO reserves the right to assert copyright protection internationally.
Rights Statement
No Copyright - United States. URI: http://rightsstatements.org/vocab/NoC-US/1.0/
The organization that has made the Item available believes that the Item is in the Public Domain under the laws of the United States, but a determination was not made as to its copyright status under the copyright laws of other countries. The Item may not be in the Public Domain under the laws of other countries. Please refer to the organization that has made the Item available for more information.