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Description

Each year, millions of people are diagnosed with cancer. In order to fight back, countless drugs are currently being developed as possible treatments for the disease. Histone deacetylase (HDAC) inhibitors are chemical compounds that can be used to reverse repressed transcription of tumor suppressor genes. They are currently used to treat several targeted cancers, but there is much room for improvement to make them work more efficiently without causing unwanted side effects. The aim of our research was to investigate new metal-binding groups to be incorporated into HDAC inhibitors and make them more class or isoform selective. In order to do this, we obtained several compounds predicted to successfully bind with zinc (Zn2+) ions and analyzed their chelating ability using nuclear magnetic resonance and ultraviolet spectroscopy. We also performed several reactions aimed at synthesizing an HDAC inhibitor with the new metal-binding group attached. Our research identified that several groups tested possessed significant ability to bind to Zn2+. Moving forward, once the metal-binding groups are incorporated, the compounds can be tested on cancer cells to determine their ability to inhibit cell growth.

Degree Level

Undergraduate

Identifier

2017_scholcel_mcdanieljade_HDACinhibitors

Publication Date

3-29-2018

Document Type

Poster

Keywords

histone deacetylase inhibitor; HDAC; anti-cancer drug; synthesis; spectroscopy

Disciplines

Medicinal and Pharmaceutical Chemistry

Advisor

L.M. Viranga Tillekeratne

Notes

consent form on file

College

College of Pharmacy and Pharmaceutical Sciences

Department

Medicinal and Biological Chemistry

File Type

application/pdf

Institution

The University of Toledo

Digital Publisher

Digital Initiatives, University of Toledo Libraries

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Rights Statement

http://rightsstatements.org/vocab/InC/1.0/

Investigation of New Metal-Binding Groups For Histone Deacetylase Inhibitors

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In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/
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