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Description

Caffeine has recently become popular as a component of topical anti-aging cosmetic products due to its wide-ranging biological activity. The aim of this study was to determine the amount of caffeine that permeated through a skin-like synthetic membrane from marketed eye creams. A prestige and a mass anti-aging eye cream for women and an anti-aging eye cream for men were selected to be studied. Physicochemical characteristics, including pH, appearance and droplet size were studied. Permeation of caffeine was tested in vitro using Strat-M®membrane on Franz diffusion cells. Caffeine was analyzed using HPLC. Appearance of the products slightly differed, their pH was similar. All three eye creams were monodisperse, the average droplet size varied between 1-3.5 μm. The mass product for women contained the highest amount of caffeine in 1 g eye cream. In this 24-hour study, the largest caffeine permeation (0.49%) via Strat-M® membrane was observed from the prestige eye cream for women. Eye creams containing caffeine will be formulated using in silico modeling and tested for in vitro release and in vitro permeation. Data from this preliminary study will guide in designing the creams. A. S. acknowledges support from the UT Office of Undergraduate Research (FYSRE).

Degree Level

Undergraduate

Identifier

2017_scholcel_SmithAmber_SkinPenetrationofCaffeine

Publication Date

3-23-2018

Document Type

Poster

Keywords

cosmetic science; pharmacy; BSPS; caffeine; eye creams; Franz diffusion cells; HPLC; skin penetration; in vitro; anti aging; permeation

Disciplines

Pharmacy and Pharmaceutical Sciences

Advisor

Gabriella Baki

Notes

consent form on file

College

Pharmacy and Pharmaceutical Sciences

Department

Pharmacy Practice

File Type

application/pdf

Institution

The University of Toledo

Digital Publisher

Digital Initiatives, University of Toledo Libraries

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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http://rightsstatements.org/vocab/InC/1.0/

Skin Penetration of Caffeine from Marketed Eye Creams

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